Pakuyesa kwaposachedwa kwa gawo 3, Tirzepatide adawonetsa zotsatira zolimbikitsa pochiza matenda amtundu wa 2.Mankhwalawa adapezeka kuti amachepetsa kwambiri shuga m'magazi ndikulimbikitsa kuchepa kwa odwala omwe ali ndi matendawa.
Tirzepatide ndi jekeseni kamodzi pa sabata yomwe imagwira ntchito poyang'ana ma glucagon-like peptide-1 (GLP-1) ndi ma glucagon-dependent insulinotropic polypeptide (GIP) receptors.Ma receptor awa amagwira ntchito yofunika kwambiri pakuwongolera kuchuluka kwa shuga m'magazi komanso kulimbikitsa kupanga kwa insulin.
Mlanduwu, woyendetsedwa ndi Eli Lilly and Company, adalembetsa anthu opitilira 1,800 omwe ali ndi matenda amtundu wa 2 omwe samamwa insulin kapena kumwa insulin yokhazikika.Ophunzira adapatsidwa mwachisawawa kuti alandire jakisoni wamlungu ndi mlungu wa Tirzepatide kapena placebo.
Kumapeto kwa mayesero a masabata a 40, ofufuza adapeza kuti odwala omwe adalandira Tirzepatide anali ndi shuga wotsika kwambiri kuposa omwe adalandira placebo.Pafupifupi, omwe adalandira chithandizo cha Tirzepatide adachepetsa 2.5 peresenti ya hemoglobin A1c (HbA1c), poyerekeza ndi kuchepa kwa 1.1 peresenti mu gulu la placebo.
Kuphatikiza apo, odwala omwe amalandila Tirzepatide nawonso adawonda kwambiri.Pafupifupi, anataya 11.3 peresenti ya kulemera kwa thupi lawo, poyerekeza ndi 1.8 peresenti ya gulu la placebo.
Zotsatira za mayesowa ndizofunikira kwambiri chifukwa cha kuchuluka kwa matenda amtundu wa 2 padziko lonse lapansi.Malinga ndi bungwe la World Health Organisation, chiwerengero cha anthu akuluakulu omwe ali ndi matenda a shuga chawonjezeka kuwirikiza kanayi kuyambira 1980, ndipo pafupifupi akuluakulu 422 miliyoni adakhudzidwa mu 2014.
"Kusamalira matenda a shuga a mtundu wa 2 kungakhale kovuta kwa anthu ambiri, ndipo njira zatsopano zothandizira odwala nthawi zonse zimalandiridwa," adatero Dr. Juan Frias, wofufuza wamkulu pa kafukufukuyu."Zotsatira za kafukufukuyu zikusonyeza kuti Tirzepatide ikhoza kupereka njira yatsopano yodalirika kwa odwala omwe ali ndi matenda a shuga a 2 omwe akuvutika kuti asamayende bwino."
Ngakhale kuti maphunziro owonjezera akufunika kuti awone kuti Tirzepatide imakhala yotetezeka komanso yogwira ntchito kwa nthawi yayitali, zotsatira zolimbikitsa za mankhwalawa muyeso la gawo lachitatu ili ndi chizindikiro chabwino kwa anthu omwe ali ndi matenda a shuga a mtundu wachiwiri.Ngati avomerezedwa ndi mabungwe olamulira, Tirzepatide ikhoza kupereka njira yatsopano yochizira matendawa ndikuwongolera moyo wa odwala.
Nthawi yotumiza: Jun-03-2023